Developing therapies to treat life-threatening rare diseases



Thalagen™ is the brand name for EGT’s gene therapy treatment for beta thalassemia, also referred to as Cooley’s anemia. To date there is no curative therapy for thalassemia, a disease characterized by the cells of the bone marrow having an inability to produce normal hemoglobin.
Trichostatin A-picture

Trichostatin A

Trichostatin A (TSA) was originally reported (1976) as a fungistatic antibiotic obtained from a culture broth of Streptomyces platensis. In 1987, its anti-proliferative activity was reported, and in 1990, TSA was found to cause an accumulation of acetylated histones in a variety of mammalian tumor
cell lines.


CG-1521 (7-phenyl-2, 4, 6-hepta-trienoyl hydroxamic acid) is an inhibitor of histone deacetylase (HDAC) in the final stages of pre-clinical development. The compound has been shown to inhibit cell proliferation of both solid and hematological cancer cells and has been extensively studied in neuroblastoma and prostate cancer models.


EGT Wins Major Victory in New York Court